Particle Therapy 2017

• Specific Aim 2: To determine the early changes in sensitive echo-

derived measures in patients undergoing RT, and how these

changes differ in proton versus photon therapy.

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Hypothesis: Early abnormalities in measures of cardiac size,

function and mechanics will differ according to RT; photon

therapy will result in worse remodeling.

Functional Alteration

Echocardiographic Measure

Ventricular Structure

LV and RV size and mass

Systolic Function

LV and RV Strain, Strain rate,

Ejection fraction

Diastolic Function

e/a, e’, a’

Ventricular/Vascular Stiffness

Ea, Ees, Ea/Ees

Systolic/Diastolic Deformation

Twist, Torsion