1532-1533 / 2605
PATHOPHYSIOLOGY
•
Brain development quick pace 3-6 Years of age
•
Due size neurons (axons, dendrits arborization,
synaptogenesis
•
Progressive myelinization until puberty
•
MAIN RX INJURY:
•
Demyelinization
→
white matter necrosis
•
Putative mechanisms:
1.
VASCULAR:
•
endothelial cells
g
hyaline degeneration
g
obliterating sclerosis
•
Delay:
years
2.
GLIAL:
•
oligodendrocytes
g
cell death
g
myelin deterioration
•
Delay:
weeks-months
•
1+2