1534-1535 / 2605
CLINICAL SYNDROMES
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Necrosis
-Risk: 50-60 Gy=01%-5%
-Non specific symptoms
-Tt: steroids, resection
●
Necrotizing
leukoencephalopathy
-Multiple peri ventricular areas of
demyelination post MTX/RT
(ALL)
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Mineralizing microangiopathy
-Seizures, ataxia, lethargy
-Intra cerebral calcif, visible on
CT/MRI
Prevention: Chemo/RT interactions
●
Neuropsychologic & intellectual
disorders
-Chemo/RT modalities, age & related
-Affects:IQ, academic
performances,reading,
attention, Math, memory, motor skills
-Prevention: RT,chemo modalities;
older age,
hemisphere sparing
●
Somnolence syndrome
-4-8 weeks post RT
-apathy, irritability, nauseas,drowziness
-Prevention: limit RT volume