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Rationale: historical perspective
• The « heroic » period : until late 90s
– 1946:Founding concept by Wilson on the potential
advantage of protons over conventional XR
– 50s: pionneering work by neurosurgeons (AVMs,
Pituitary)
– 70s: interest from ophthalmological, and then
radiotherapy communities
–
« niche » of rare & highly selected indications