1706-1707 / 2605
•
Phase I/II trial. 20 women with T-1 breast Ca, neg. margins after
lumpectomy
•
PTV: lumpectomy cavity plus 1.5-2.0 cm, minimum 5mm distance to
surface/skin
•
32 Gy(RBE) total dose: 4 Gy (RBE) B.I.D. over 4 days
•
1-3 field arrangements overall, 1 field treated per day only
•
„Skin dose per field approached maximum dose“, Single field per day =
full 4 Gy skin dose. (MGH, passive scatttering )
•
Observation: Median F/U 12 months (8-22)
increased acute toxicity:
80% moderate to severe skin color changes
22% severe moist desquamation
Accelerated Partial-Breast Proton Therapy: Initial MGH Experience
Kozak, Taghian et al. IJROBP 66(3):691, 2006