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BRE008-12 Phase II Study of Postoperative, Cardiac-Sparing Proton Radiotherapy for Patients
with Stage II/III, Loco-Regional, Non-Metastatic Breast Cancer Requiring Whole Breast or Chest
Wall Irradiation with Lymph Node Irradiation
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BREAST CONSERVING THERAPY:
Whole breast and regional lymph nodes (axilla levels I-III, supraclavicular*):
45 - 50.4 Gy (RBE) in 25 - 28 fractions of 1.8 Gy (RBE) per fraction
and
Internal mammary node chain (IMC) for stage III patients*:
45 - 50.4 Gy (RBE) in 25 - 28 fractions of 1.8 Gy (RBE).
+
Lumpectomy tumor bed boost to a total cumulative dose of
61.2 - 66.6 Gy (RBE) in 1.8 Gy (RBE) per fraction
MASTECTOMY:
Chest wall and regional lymph nodes (axilla levels I-III, supraclavicular*):
45 -50.4 Gy (RBE) in 25 - 28 fractions of 1.8 Gy (RBE).
and
Internal mammary node chain (IMC), for stage III patients*:
45 - 50.4 Gy (RBE) in 25 - 28 fractions of 1.8 Gy (RBE).
+
Chest wall scar boost (optional): for a total cumulative dose of 61.2 Gy (RBE)
in 1.8 Gy (RBE) per fraction.
PI’s: E. Hug, M. Fagundes, M. Pankuch, N. Schreuder et al. – opened 2/2013.