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Pignon JP et al 2009

RT + concomitant

5-FU / platin

RT

R

is

k

o

f

fa

il

u

r

e

(

%

)

0

2

0

4

0

6

0

8

0

10

0

Time from randomisation

(years)

50.2

%

63.2

%

16

%

18.9

%

Loco-regional

Distant

0 1 2 3 4 5 6 7

³

8

HR: 0.66

Concomitant RT-CT :

where does the benefit come from ?

Results in H&N Tumors