244-245 / 2605
The Domain of Carbon Ion Therapy at NIRS
•
with large proportion of hypoxic cells
•
do not well re-oxygenate
•
with broad-shouldered dose survival curves by low LET
radiation (
small α
҈
β ratio )
•
slowly proliferating
Tumors ; biological view points for high LET beam
•
empirically radio-resistant, such as sarcomas,
melanoma, RCC, thyroid ca, and re-irradiation
•
located close to radiosensitive organs ; para-spinal
•
Not candidate to other therapies such as second surgery, limb
amputation, concurrent chemo-radiation etc.
Tumors ; clinical context (practical) mainly conformality