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Dealing with uncertainties
Single voxel dose ‘spectrum’
due to positioning errors.
Each is possible on each
fraction of delivery
Voxel dose ‘spectrum’ due to
positioning errors after n-
fractions.
Positioning errors assumed to
be random errors
Example reduction of single
voxel dose uncertainty (over
full treatment) as a function of
number of fractions
Fractionation
1 fraction
30 fraction
Lowe et al (2016)
Robust optimisation – What is a good robustness metric?