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Principles of the LEM
(Scholz et al. Rad Env. Biophys. 1997)
Nucleus
Nucleus
X
lethal
dV
V
zyxdS
N
)) , ,(( ln
Input parameters:
• Particle spectrum
• Radial Dose distribution:
•
Photon dose response
•
Transition from LQ to
linear survival at doses
>1000Gy
• Target size: cell nucleus
2
1
r
rD
)(
c
E r
max
)
(
2
) (
DD
e DS