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0.0

0.5

1.0

1.5

2.0

2.5

3.0

3.5

4.0

1

10

100

H160SOBP6cm

He150SOBP6cm

C290mono

C290SOBP6cm

C400SOBP6cm

Ne230mono

Ne400SOBP

Si490mono

Fe200&500mono

Co60γray

Xray200kV

MK model

RBE

10,HSG

y

*

(keV/

m)

More accurate modeling of the HSG 

response with fragments

Advantageous for scanning field where 

energy and particle species are highly 

complex.

D10 RBE

18

Depth survival

Dose survival

(middle of SOBP)

Verification of MKM with HSG cells 

(courtesy of N. Matsufuji)