680-681 / 2605
Protons in pediatrics
Clinical experience
AUTHOR [Ref]
(Year)
SITE/ TUMOUR TYPE
# Pts
(F-UP)
TOTAL DOSE, (CGE)
RESULTS
Mc Allister, B [ 33]
(1997)
HN+brain
28
(m:25)
m: 54
(41-70)
mix P/X+P
CL:24/28, 2 épilepsies,
1 hormon failure,
1 cataract
Hug, EB [34]
(2002)
Astrocytomas
Low grade
27
(M:39)
M:55
(50-63)
X/X+P
OS: 85%, LC: 78%,
Complic : 4/27 pituitary failures,
1 radiological radionecrosis
Hug, EB [35]
(2002)
Skull base
sarcomas
29
50-78
CL/SG 5A: 72%-56%;
complic:2 sensori-motor deficits
Noel, G [36]
(2003)
CNS
17
(M:27)
m:60
(50-69)
X+P
LC + OS 3Y:92%+93%;
Complic : 1 cerebellar, 1 pituitary failure,
1 memory loss
Yock, T [32]
(2005)
RMS orbit
7
(m:75)
m: 46
(40-55)
P
LC: 6/7; no late toxicity
Luu, QT [37]
(2006)
Craniopharyngioma
16
(M:60)
?
(50-59)
P
CL: 14/15; SG:12/15;
complic: pituitary failure,
1 vascular, 1 meningioma,
Timmermann, B [38]
(2007)
Trunk+HN
sarcomas
16
(m:18)
m:50
(46-61)
P
LC:12/16
Habrand, JL [39]
(2008)
Skull base
sarcomas
30
(M:26)
M: 68, P/X+P
OS/DFS 5A: Chordomas: 81%/77%; chondrosarcomas: 100%/100%;
pituitary failures: half, 1 visual loss