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RTOG 0617:

60 Gy

74 Gy

Local Failure

30%

39% (ns)

PFS

29%

21%

Distant mets

46%

51%

Overall Survival

57%

44% (ss)

Median survival

29 months

20 months

Trial was stopped because of increased risk of fatalities in high-dose arm

Does this even make sense?