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Summary

modified from Coleman CN,

Radiotherapy and Oncology

46: (1998)

DNA

repair

DNA

damage

cell

death

cell cycle

effects

stress

response

gene

activation

growth

factors

lipid

peroxidation

O

2

O

2

.

receptor

signal

transduction

external

effectors

O2, nutrients etc.

endocrine factors

Neighbouring tumor or stroma cells

inflammatory

molecules

vasculogenesis