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Inherent or acquired tumor cell resistance
Mutated tumor suppressors
(e.g. p53)
DNA repair gene amplification
Activation of pro-survival oncogenes
(e.g. EGFR)
Up-regulation of antioxidative enzymes
(e.g. superoxide dismutase, catalase)
Evading cell death
(e.g. BCl2, Survivin)
Human Ovarian Carcinoma
Biological factors