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Toxicity reduction by protons (retrospective analysis)
3D CRT
IMRT
Protons
Dose
63 Gy
63 Gy
74 CGE
% patients stage IIIA-B22
87%
91%
87%
Toxicity
Esophagitis – G3+
18%
44%
5%
Pneumonitis – G3+
30%
9%
2%
(1) Samir Sejpal et al., “Early findings on toxicity of proton beam therapy with concurrent chemotherapy for nonsmall cell lung cancer,” Cancer e-publication ahead of print (January 24,
2011): 1- 10
(2) Retrospective analysis. In lieu of selection criteria, percentage of patients with Stage IIIA-IIIB were summarized
Note: Grade 3 and higher toxicities result in significant medical intervention including hospitalization to manage adverse side effects`
NSCLC treated with radiation therapy + chemotherapy at M.D. Anderson(1,2)




