©2012AOAC INTERNATIONAL
G
UIDELINES
FOR
S
TANDARD
M
ETHOD
P
ERFORMANCE
R
EQUIREMENTS
AOACO
FFICIAL
M
ETHODS
OF
A
NALYSIS
(2012)
Appendix F, p. 6
Table A1. Performance requirements
Classifications of methods
a
Quantitativemethod
Qualitativemethod
Identificationmethod
Main component
b
Trace or contaminant
c
Main component
b
Trace or contaminant
c
Parameter
Single-laboratory validation
Applicable range
Bias
d
Precision
Recovery
Limit of quantitation (LOQ)
Applicable range
Bias
d
Precision
Recovery
LOQ
Inclusivity/selectivity
Exclusivity/cross-reactivity
Environmental interference
Laboratory variance
Probability of detection
(POD)
e
Inclusivity/selectivity
Exclusivity/cross-reactivity
Environmental interference
Laboratory variance
POD atAMDL
f
Inclusivity/selectivity
Exclusivity/cross-reactivity
Environmental interference
Probability of identification
(POI)
Reproducibility
RSD
R
or target
measurement
uncertainty
RSD
R
or target
measurement
uncertainty
POD (0)
POD (c)
LaboratoryPOD
g
POD (0)
POD (c)
LaboratoryPOD
g
POI (c)
LaboratoryPOI
a
SeeAnnexB
for additional information on classification of methods.
b
≥100 g/kg.
c
<100 g/kg.
d
If a referencematerial is available.
e
At a critical level.
f
AMDL=Acceptableminimumdetection level.
g
LPOD=CPOD.
