312 / 884
REFLECTIONS:
- The benefit of ADT in combination with EBRT (even with dose-escalated EBRT)
may be because of
compensation for suboptimal radiation dose and less effective
therapy.
- Because of the very high intraprostatic dose and excellent disease control,
ADT is
likely to have less biologic effect with PB
, except perhaps in cases with very high-
volume diesease or through spatial cooperation for suppression of micrometastic
disease
- Addition of ADT to PB in IR and HR patients has been shown to decrease 2-yr post
PB positive biopsy rate from 14% to 3,5%
Lo et al, Int J Radiat Biol Phys, 2015;91:745-751
Stone et al, Int J Radiat Biol Phys, 2010; 76:355-360
Stone et al: Mol Urol 2000; 4(3): 163-168