308 / 884
Even short term ADT gives an absolute increase 5,3% at 10 years ! (Kobutek et al)
Re-analysis of 6 RCTs (Albertsen et al )
- the increase in cardio-vascular mortality and morbidity might be an LHRH agonist class
effect
- significantly less CVD events in men treated with LHRH antagonists vs LHRH agonists
(HR: 0,44 - 95% CI 0,26-0,74 - p=0,002)
Pronounce NCT02663908: RCT comparing major CV events with LHRH
agonists vs antagonists in patients with pre-existing CV morbidity
Kobutek et al, Int J Radiat Oncol Biol Phys 2014;90:S15
Albertsen et al, Eur Urol 2014;65:565-573