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Normal tissue effects and injury – Acute effects
LDR prostate brachytherapy - urothelium
Acute effects
symptoms
outcome
management
urothelium Inflammation,
oedema,
hyperaemia,
cellular loss with
loss of epithelial
integrity
irritative and obstructive –
•
Burning
•
urgency
•
frequency
•
nocturia
•
urge incontinence
•
urinary retention
•
haematuria
•
spasmodic pain
•
Mostly self-limiting
•
Resolves
spontaneously
•
Symptoms subside
gradually as radiation
diminishes.
•
Typically takes
6-12 months
•
Do not generally
convey risk of late
complications
Supportive
Reassurance
Pharmacological –
•
NSAID
•
Cortisone
•
cholinergic agonists
•
alpha-adrenergic blocking
agents
•
anticholinergic agents
•
tricyclic antidepressants
(TCAs)
•
sympathomimetic agents
•
Dr Stone’s urethral
instillation formula
Catheterization for retention