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• Electrical cavernous nerve
stimulation increases
pudendal blood flow and
provides rapid increases in
intracavernosal pressure
(ICP)
• Intracavernosal injection of
a nitric oxide donor, sodium
nitroprusside, produces
slow increases in ICP but
has no effect on pudendal
flow
0
20
40
60
80
100
0
100
200
ICP, mmHg
Blood Flow, ml/min
Nerve stim
SNP ic
60s
Illustrates importance of flow-mediated vasodilation in the initiation and
maintenance of penile erection in preclinical model
Wayman C et al. ESSM. 4-7 December2005. Poster M-05-141.
Rate of Erection Hardness (ICP) Increases With
Increased Pudendal Flow to the Penis
Intracavernosal
Pressure (ICP)
Pudendal flow