SBRT2015

Study arms

SABR: 66 Gy in 3 fractions

(to isocenter)

CFRT: 70 Gy in 35 fractions

Primary End-

point

Freedom from tumor

progression at 36 months

Secondary end-

points

OS at 36 months

Toxicity, QoL

Total enrolled

102 patients (completed)

Randomised SPACE trial of conventional radiotherapy (CFRT) vs

SABR (NCT019207)

Similar local failure rates

( 11% SABR v s 13%

C F R T ) , r e g i o n a l

recurrences (7% vs 8%,

distant metastases (24%

vs 23%)

F e w e r c a s e s o f

pneumonitis (16 vs 34%)

and esophagitis (9 vs

32%) seen in SABR arm.

Any G3-5 toxicity seen in

16 versus 18%

Nyman J, ESTRO 2014

Is conventional radiotherapy inferior?