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RTOG 0813 Trial: Adverse events
•
G2+ pulmonary toxicity in
4/8
at10.0 Gy/fr,
5/14
at 11.0 Gy/fr,
15/38
at 11.5 Gy/fr, and
10/33
at 12.0 Gy/fr pts.
•
4/100 (4%) had fatal hemoptysis potentially attributable to SBRT
Dose/fraction
(total = 5 fr)
Patient
numbers
Grades 3-5 toxicity
(CTCAE v4.0)
G3
G4
G5
*
10 Gy
8
10.5 Gy
7
1
11 Gy
14
1
11.5 Gy
38
4
2
12 Gy
33
5
1
1
!
*
Gr 5 all due to hemoptysis; mean 13 months post-SBRT
Bezjak A, WCLC Denver (Oral 19.03, 8
th
September 2015)