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Chemotherapy for Early Stage Trial (CHEST)
•
Phase III study in 270 patients (only 1 case with N2 disease)
randomized to either 3 cycles of chemotherapy followed by
surgery, or surgery alone
•
Median age: 62; 72% had ECOG performance score 0
Surgery for early-stage NSCLC
Scagliotti G, JCO 2012
Chemo + surgery
surgery
Perioperative
mortality
rate
3%
4%
Complete resection rates
88%
84%
Failure
at primary site
9.3%
10.6%
Lymph node
relapses
13.2%
6.4%