Schwartz
IJROBP 2005
“Dose heterogeneity is an option to further escalate
the dose in the target rather than a price to pay for
using IMRT”
Dose escalation 3D vs IMRT: 6% vs 17-35%
Grills
Dose escalation: IMRT>>25-30%
3D vs IMRT: PTV Dose escalation in the target
IJROBP 2003
St Hilare
Radiot Oncol 2009
Dose escalation: >78 Gy in 5/7 cases