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Clinical relevance of the serial cost function

1 ,

1

1

=

=

k D

N

F

N

i

k

i

serial

directly related to…

k

N

i

k

i

serial

D

N

EUD

=

=

1

1

For rectal complications (grade>=2 bleeding)

ESTRO IMRT course 2016

IMRT optimization: algorithms&cost functions

London April 4th, 2016

-64-

M. Söhn et al. 2007 (IJROBP 67(4))

Quantec-Report: J. M. Michalski et al. 2010 (IJROBP 76(3))

k = ~13.5

EUD

serial

[Gy]

strong clinical evidence, that NTCP is clearly

related to rectal EUD!