Clinical relevance of the serial cost function
1 ,
1
1
≥
=
∑
=
k D
N
F
N
i
k
i
serial
directly related to…
k
N
i
k
i
serial
D
N
EUD
∑
=
=
1
1
For rectal complications (grade>=2 bleeding)
ESTRO IMRT course 2016
IMRT optimization: algorithms&cost functions
London April 4th, 2016
-64-
M. Söhn et al. 2007 (IJROBP 67(4))
Quantec-Report: J. M. Michalski et al. 2010 (IJROBP 76(3))
k = ~13.5
EUD
serial
[Gy]
strong clinical evidence, that NTCP is clearly
related to rectal EUD!