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Parameter derivation
•
Parameters are fitted to outcome data and DVHs (fractionation corrected)
using the
maximum likelihood
method: finds parameters which makes
current observation as likely as possible
•
Outcome data generally binary (tox, no tox)
•
Model is associated with the characteristics of the registered outcome data:
– Endpoint, including grade
05/04/2016
– Co-morbidity, concomitant
treatments etc.
•
The confidence interval of the
parameters depend on the quality of
the data they’re fitted to, and the
sample size