206-207 / 2953
Second Malignancies
Hall et al.
(
IJROBP 2003
) IMRT may increase second malignancy
rate from 1% to 1.75%
Higher MU’s, increased leakage resulting in increase body dose,
larger volume of normal tissue receiving a lower dose
But, most second malignancies seen in the moderate or high dose
volume
Paediatrics
-
More sensitive to RT induced cancers
-
Scattered radiation in small body
-
Genetic susceptibility
12