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Late toxicity after 3D conformal radiotherapy
Late toxicity and limb function are related to treatment volumes and
RT dose
Soft tissue fibrosis
Lymphoedema
Bone fractures, joint stiffness
Rates of ≥grade 2 fibrosis in 48.2% with post-operative RT
Negative impact on function
8
50 Gy/25# pre-op
66 Gy/33# post-op
Davis et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in
extremity soft tissue sarcoma. Radiotherapy and Oncology 2005, 75:48–53.