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4 R’s
of radiobiology
•
R
epair
➢
Repair of sub-lethal DNA damage
•
R
edistribution
➢
Radiosensitivity depends on phase in the cell cycle
→
redistribution changes radiosensitivity
•
R
epopulation
➢
Cell divide during a radiotherapy treatment
•
R
eoxygenation
➢
Radiosensitivity changes due to change in oxygenation