1259 / 1778
3
32 „events“ in 151 patients
Actuarial rate 3y: 24%
Dose Effect relationship for late rectum side effects
based on points (ICRU reference points)
Vienna 93-97
BED ~120-130 Gy
3
„cut-off
level“ in recent experience
Iso-effective dose in 2Gy/fr
~ 70-80 Gy
ab3
,2Gyfr
no clear dose effect relations
bladder, sigmoid, vagina
More evidence: overview in Gerstner et al. R&O 2004
J. Fowler, Knocke, Pötter 1998 unpublished