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Limitations of the EQD2 model for BT
➢
Chemotherapy is not taken into account
➢
Uncertainty increases for single fraction dose values >10Gy
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Only cell repair is considered
➢
/
values and T
1/2
are under discussion
(E.g. tumour type prostate, OAR etc.)
➢
dose and dose rate inhomogeneity within BT volume is not considered
➢
Overall uncertainty of the biological dose calculation (values) in the
range of ~10% -> Reasonable rounding of values