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Patient reported
subjective symptoms
Patient reported
objective symptoms
Physician assessed
objective symptoms
Analytic outcomes
(lab / imaging)
Patient reported impact of
symptoms on ADL
objective
subjective
clinical decision / medical intervention
Patient reported complex
multidimensional concepts
Combined information is
translated by physician
into medical terms and grades
Symptoms e.g., rectal
discomfort,
passing blood or mucus;
medical intervention indicated;
limiting instrumental activities
of daily life
Depends on the interpretation
of the physician
Translation problems may be
assumed!
Physician assessed morbidity
Common Toxicity Criteria of AE