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Agreement physician assessed vs. Patient reported symptoms
Kirchheiner et al. SUON 2012
N=223 cervical cancer, CTCAE v3 vs. EORTC C30 + CX24
3 months after end of definitive radiochemotherapy
>1 time/hour, urgency,
catheter indicated
Increase >2 times of
normal, but < hourly
Increase in frequency
or nocturnia up to 2
times of normal,
enuresis
None
very much
quite a bit
a little
not at all
G0 G1 G2 G3 CTCAE Urinary frequency
EORTC : Did you pass water / urine frequently?
Discrepancy:
Patient reported
symptom
“quite a bit” to ”very
much” in EORTC QLQ
→ CTCAE grading 0
not at
all
a little
quite
a bit
very
much