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External beam radiotherapy (EBRT) was initially 3D but since 2011 IMRT is performed. All the
cases received 45 Gy over 5 weeks.
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In cases with lymph node remanents following lymphadenectomy or findings of extracapsular
extension in some lymph nodes, a lymph node boost to 56-60 Gy was carried out after
brachytherapy. Patients included in the EMBRACE II study received an integrated boost at a
dose of 55-57 Gy according to the pelvic or paraaortic localization, respectively.
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Before the availability of combined intracavitary-interstitial applicators, patients with
macroscopic residual parametrial disease received a parametrial dose to achieve 60 Gy after
brachytherapy, taking into account the parametrial doses of the brachytherapy.
RT-QT
RT-QT
RT-QT RT-QT
RT-QT
BQ BQ
Nodal boost integrated
44 d