439 / 1778
Concurrent Carboplatin based studies
Study
n Carboplatin
dose-schedule
CR
n (%)
Med. FU
(M)
DFS n
(%)
Hemato. Gr 3–4
Corn, 1999 7 60mg/m2,
weekly 3
3 (43) -
-
-
Duenas-
Gonzales,
2003
24
100, 116, 133,
150mg/m2,
weekly
18 (75) 8
Leucopenia,
Neutropenia
Higgins, 2003 31 60–90mg/m2,
weekly
28 (90) 12
23 (74)
<2%
Muderspach,
1997
22 30–50mg/m2,
twice a week
19 (86) 15
11 (50)
Aneamia 13.6%,
Neutropenia 4.5%
Micheletti,
1997
12
12mg/m2, daily 9 (75) 20
LC-8 (66) Leucopenia 8.3%
Dubay, 2004
21
300mg/m2, every
3 weeks
-
33
LC-16
(76)
Aneamia 9.5%,
Neutropenia 9.5%
Veerasarn,
2007
235 100mg/m2,
weekly
170
(72)
11.8
176 (75) Leucopenia 2%,
Neutropenia 2%
No randomized phase III study