442 / 1778
• sabotage repair of sublethal cell injury
• prevent HIF-regulated hypoxic cell survival.
• Dunton and coworkers (2002) maximal tolerance dose (MTD) with
RT
– 1 mg/m
2
daily for 5 days on days 1–5 and 22–26 concomitantly
– Grade III anemia in one case
– Grade II leukopenia in two cases
– Dose limiting toxicity was not reached.
• Bell and associates (2001) Brachy with topiotecan
– 0.5 mg/m
2
.
• Ongoing: Weekly IV Topotecan and Cisplatin With Radiation in
Cervical Carcinoma NCT00257816
– University of california
– 2004-9
OTHER RADIO-SENSITIZERS
Topotecan