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• Intratumoral protein levels of VEGF are increased in patients with cervical cancer
when compared to normal cervical tissue (1)
• Increasing intratumoral levels of VEGF correlated with (1):
– higher stage
– increased risk of LVI
– increased risk of lymph nodes metastasis
• Higher VEGF expression was an independent prognostic factor for poor disease-
free and overall survival (2)
(1)Cheng et al. Obstet Gynecol 2000;96:721-6
(2)Loncaster et al. Br J Cancer 2000;83(5):620-5
CRT AND BIOLOGIC AGENTS
VEGF IN CERVICAL CANCER