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Cell - cell communication
Secreted Factors
Non-targeted effects of IR
• Recent shift in
conventional paradigm
of radiobiology
• Targeted vs Non-
targeted effects
• Non-Targeted effects
– Bystander effects (RIBE)
• Abscopal = clinical
manifestation
– Genomic instability
(RIGI)
– Low dose
hypersensitivity
– Adaptive response
• Occur >0.5Gy IR
GJIC
Nucleus
Radiation
Courtesy of Orla Howe, DIT