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Which patients benefit from High Dose
irradiation and concomitant chemotherapy?
EORTC
T > 4 cm
or pos LN
UKCCCR
all T
all N
108 patients
585 patients
45 Gy / 5 wks
Boost (20 Gy)
or APRA
®
Cycle Cycle
45 Gy / 5 wks
.
#
1
# 2
5 FU
= 750 mg /m
2
d 1-4 et d 29 - 32
MITO
= 15 mg/m
2
d 1