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Which patients benefit from High Dose

irradiation and concomitant chemotherapy?

EORTC

T > 4 cm

or pos LN

UKCCCR

all T

all N

108 patients

585 patients

45 Gy / 5 wks

Boost (20 Gy)

or APRA

®

Cycle Cycle

45 Gy / 5 wks

.

#

1

# 2

5 FU

= 750 mg /m

2

d 1-4 et d 29 - 32

MITO

= 15 mg/m

2

d 1