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Chemoradiation + Brachy

RTOG 92-07

50 Gy EBT + 3 x 5 Gy HDR

60 Gy EBT + 2 x 5 Gy HDR

3 x 5FU / CDDP / MMC

4 x 5FU / CDDP

Applicator diameter 4-6 mm,

prescrption 10 mm

CR 73%

G3 acute Tox 58%, G4 late

Tox 8%

Applicator diameter 10-14

mm, prescription @ 5mm

3 + 5 y Survival: 27% and

18%

G3-4 late Tox 11%

Calais et al., Int. J. Radiat. Oncol.

Gaspar et al., Int. J. Radiat. Oncol.

Biol. Phys. 37; 593-599, 1997

Biol. Phys. 38; 769-775, 1997