1836 / 1840
Chemoradiation + Brachy
RTOG 92-07
50 Gy EBT + 3 x 5 Gy HDR
60 Gy EBT + 2 x 5 Gy HDR
3 x 5FU / CDDP / MMC
4 x 5FU / CDDP
Applicator diameter 4-6 mm,
prescrption 10 mm
CR 73%
G3 acute Tox 58%, G4 late
Tox 8%
Applicator diameter 10-14
mm, prescription @ 5mm
3 + 5 y Survival: 27% and
18%
G3-4 late Tox 11%
Calais et al., Int. J. Radiat. Oncol.
Gaspar et al., Int. J. Radiat. Oncol.
Biol. Phys. 37; 593-599, 1997
Biol. Phys. 38; 769-775, 1997