1837 / 1840
Improvement in Chemoradiation
Without Brachytherapy
366 resectable tumors (T2-3N0-1M0)
Randomization RT vs. CRT followed by resection
41.4 Gy (1.8) + paclitaxel 50 mg/m2
+ carboplatin AUC = 2 mg/ml/min
92% R0 resections
Pathologic CR 29%
Median Survival:
RT 24 mths vs. CRT 49.4 mths.
3 y OS:
RT 44% vs. CRT 58%
Van Hagen, New Engl J Med 2012;366:2074-2084