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Immune-related adverse events
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Grade 3 or higher irAEs are observed in 11–22% of patients
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LUNG : includes interstitial pneumonia, pneumonitis,
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BOWEL colitis, gastrointestinal inflammation, stomatitis , increased alanine
aminotransferase/aspartate aminotransferase levels, pancreatitis,
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RENAL nephrotic syndrome,
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PANCREAS fulminant type 1 diabetes mellitus,
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BONE MARROW : myelodysplastic syndrome, leukopenia, thrombocytopenia,
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OTHER : septic meningitis, pyrexia, infusion reaction, joint swelling, pain, tumor
progression, and arrhythmia.