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Nivolumab in Patients With Relapsed or Refractory Hematologic

Malignancy: Preliminary Results of a Phase Ib Study.

Lesokhin A et al J Clin Oncol. 2016 Aug 10;34(23):2698-704.

Phase 1 study, 81 patients with B-cell malignancies

(NHL

n

= 31, including DLBCL [

n

= 11], and FL [

n

= 10]) other B cell

NHL, T cell lymphoma (

n

= 23), and multiple myeloma (

n

= 27); treated

with Nivolumab 3 mg/kg (NCT01592370).

All patients had received prior systemic treatment regimens (median 3;

range, 1–12).