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Solitary or localized plasmacytomas are rare diseases that account for less than
10% of all plasma cell neoplasms
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Similar to MM but without infiltration of the bone marrow, these neoplasms are
composed of sheets of plama cells involving bone or soft tissue
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When the lesion is isolated in bone, the disorder is called
Solitary Bone
Plasmacytoma Bone (SBP)
[mostly occurs in the bones of the axial skeleton]
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When in soft tissues (less common: 20 to 30% of cases), the lesion is called
Solitary Extramedullary Plasmacytoma (SEP or EMP)
, occurring mostly
(80% of the time) in the head and neck region (nasal cavity, paranasal sinuses,
nasopharynx)
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SBPs are found predominantly in men (male-to-female ratio of 2:1) and at a
median age of 55 years (younger age than MM), and are slightly more common
than EMPs