250 / 1631
Bröckelmann et al; EHA 2016
HD10:
Second Neoplasia
298
233
93
15
298
228
86
5
295
231
83
11
299
222
88
6
Pts. at risk
0 12 24 36 48 60 72 84 96 108 120 132 144 156 168 180
Time [months]
0.0
0.1
0.2
0.3
0.4
0.5
Cumulative incidence +/- 95%-CI
2ABVD+20Gy
2ABVD+30Gy
4ABVD+20Gy
4ABVD+30Gy
10-year estimate [95%-CI]
4ABVD+30Gy 8.4% [4.6% to 12.3%]
4ABVD+20Gy 6.3% [2.8% to 9.8%]
2ABVD+30Gy 7.5% [3.7% to 11.3%]
2ABVD+20Gy 8.9% [4.8% to 13.0%]
Median observation time 98 months
→
No difference in SIR for any SN: A= 2.1, B= 1.5, C= 1.6, D= 2.1
compared to the age- and sex-specific incidence in the German general population