256 / 1631
532 517 492 472 442 418 395 362 333 307 282 255 228 209 183 152
532 512 487 466 437 401 364 330 312 285 255 228 200 176 157 134
Pts. at risk
╵
╵
╵
╵╵╵╵ ╵╵╵ ╵ ╵ ╵╵╵╵ ╵╵ ╵ ╵╵╵╵╵╵╵╵╵╵ ╵ ╵╵ ╵╵╵ ╵╵╵╵ ╵╵╵╵╵╵ ╵╵╵╵ ╵ ╵╵╵╵ ╵╵ ╵╵╵╵╵ ╵╵ ╵ ╵╵ ╵ ╵╵ ╵╵ ╵╵╵╵
╵╵ ╵╵╵╵╵ ╵╵╵╵╵╵
╵╵ ╵╵╵╵╵╵╵ ╵╵╵╵ ╵╵╵╵╵╵╵╵╵╵╵ ╵
╵╵ ╵ ╵
╵╵
╵╵╵
╵╵╵ ╵╵ ╵╵
╵ ╵╵╵╵╵
╵ ╵╵╵
╵╵ ╵ ╵
╵
╵
╵╵╵ ╵
╵╵ ╵╵ ╵ ╵╵ ╵ ╵╵╵╵╵
╵
╵╵╵ ╵╵╵ ╵╵╵╵╵╵╵╵ ╵ ╵╵ ╵╵╵╵╵╵╵╵╵
╵ ╵ ╵
╵ ╵
╵ ╵╵╵╵ ╵ ╵ ╵ ╵╵╵╵╵╵ ╵
╵╵╵╵╵ ╵╵╵╵╵
╵╵╵ ╵╵
╵
╵╵
╵╵╵ ╵╵
╵
╵ ╵ ╵ ╵ ╵
╵╵ ╵ ╵ ╵ ╵
0 12 24 36 48 60 72 84 96 108 120 132 144 156 168 180
Time [months]
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
PFS rate
IF
EF
15 year estimate [95%-CI]
EF:
72.7% [68.2% to 77.2%]
IF:
73.8% [69.2% to 78.3%]
diff: 1.1% [-5.3% to 7.5%]
Hazard Ratio 0.98 [0.76 to 1.25]
Median observation time 153 months
532 523 511 499 477 461 445 424 405 381 354 326 300 273 244 203
532 531 518 507 490 461 433 410 391 367 346 319 291 260 228 197
Pts. at risk
╵
╵ ╵
╵ ╵╵ ╵╵╵╵╵ ╵╵╵ ╵╵ ╵╵╵ ╵╵╵ ╵╵ ╵╵╵╵ ╵ ╵╵╵ ╵ ╵╵ ╵ ╵╵╵ ╵╵ ╵╵ ╵╵ ╵ ╵╵╵╵ ╵╵ ╵ ╵╵ ╵╵ ╵╵╵╵╵ ╵ ╵╵╵ ╵ ╵╵ ╵ ╵╵ ╵╵╵╵╵╵ ╵╵╵╵ ╵ ╵╵╵
╵╵
╵╵ ╵
╵ ╵╵ ╵ ╵╵ ╵ ╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵ ╵╵╵╵╵ ╵╵╵╵╵╵╵ ╵ ╵╵╵╵╵ ╵╵╵╵ ╵╵╵
╵ ╵╵ ╵ ╵╵ ╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵ ╵
╵ ╵ ╵╵╵ ╵╵╵ ╵╵╵
0 12 24 36 48 60 72 84 96 108 120 132 144 156 168 180
Time [months]
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
Overall Survival rate
IF
EF
15 year estimate [95%-CI]
EF: 80.5% [76.7% to 84.3%]
IF:
82.4% [78.7% to 86.0%]
diff: 1.8% [-3.4% to 7.1%]
Hazard Ratio 0.88 [0.66 to 1.16]
Median observation time 174 months
PFS
OS
Bröckelmann et al; EHA 2016
HD8 in early unfavorable HL
Long-term outcome