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HD8: Second Neoplasia

Trend towards increased SIR with EF: 3.6 (2.9-4.0) vs. 2.6 (2.0-3.3)

compared to the

age- and sex-specific incidence in the German general population

532

426

288

151

16

532

423

261

134

11

Pts. at risk

0 12 24 36 48 60 72 84 96 108 120 132 144 156 168 180 192 204 216 228 240

Time [months]

0.0

0.1

0.2

0.3

0.4

Cumulative incidence +/- 95%-CI

0.2716

p =

IF

EF

15-year estimate [95%-CI]

EF: 17.1% [13.2% to 21.1%]

IF:

14.2% [10.4% to 18.1%]

diff: -2.9% [-8.4% to 2.6%]

Median observation time 153 months

Bröckelmann et al; EHA 2016