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Summary of FDG PET in Early HL
• Using FDG PET it may be possible to identify a group of patients with an
excellent “early” outcome from chemotherapy alone
• EORTC H10 trial – failed to achieve this goal
• Favorable subgroup: 14.2% positive early PET scan
• UK NCRI RAPID results were achieved in the setting of
• Very conservative definition of PET negative 25.3 % PET positive
• Quality controlled PET image acquisition / Central review of PET images at
the Core Lab
• High quality reproducible PET required to deliver such results
• Longer follow-up is required to establish the impact of a PET negative
approach on 10 and 20 year survival and cause of death