412 / 1631
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PD-1 engagement by its ligands results in transient down-regulation of T-
cell function (T-cell exhaustion).
•
Nivolumab (BMS) and Pembrolizumab (MSD) fully human/humanized anti-
PD-1 antibody selectively blocking the PD-1 and PD-L1/PD-L2 interaction.
•
PD-1 blockade through monoclonal antibody therapy has single-agent
activity in a range of solid tumors
PD-1 Blockade
Brahmer et al; NEJM 2012;366:2455. Topalian et al; NEJM 2012;366:2443-54